日本薬物動態学会
会長 山添 康
編集委員長 千葉 寛
2009年度DMPK三賞が決定しましたのでお知らせします。各賞の第一位の論文（総説、原著論文）の全著者について、第24回年会時に盾あるいは賞状の授賞式を行います。
1. 編集委員が選ぶ最優秀論文賞
(DMPK Editors’ Award for the Most Excellent Article in 2008)
1st Place
著者，所属：Masakiyo HOSOKAWA1), Tomomi FURIHATA2), Yumiko YAGINUMA2), Naoko YAMAMOTO2), Natsuko WATANABE2), Eiko TSUKADA2), Yoshiko OHHATA2), Kaoru KOBAYASHI2), Testuo SATOH2) and Kan CHIBA2)
(1)Laboratory of Drug Metabolism and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba Institute of Sciences,2) Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University)
論文題目：Structural Organization and Characterization of the Regulatory Element of the Human Carboxylesterase (CES1A1 and CES1A2) genes. Drug Metabolism and Pharmacokinetics 23(1), 73-84 (2008)
2nd Place
著者，所属：Norihiko IWAZAKI, Kaoru KOBAYASHI, Kaori MORIMOTO, Mai HIRANO, Sachiyo KAWASHIMA, Tomomi FURIHATA and Kan CHIBA
(Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University)
論文題目： Involvement of Hepatocyte Nuclear Factor 4alpha in Transcriptional Regulation of the Human Pregnane X Receptor Gene in the Human Liver. Drug Metabolism and Pharmacokinetics 23(1),59-66 (2008)
3rd Place
著者，所属： Kayoko MAEZAWA1), Kenji MIYAZATO1), Tamihide MATSUNAGA1), Yasuyuki MOMOSE1), Tetsuya IMAMURA2), Kohei JOHKURA2), Katsunori SASAKI2) and Shigeru OHMORI1)
(1)Department of Pharmacy, Shinshu University Hospital,2)Department of Anatomy and Organ Technology, Shinshu University School of Medicine)
論文題目：Expression of Cytochrome P450 and Transcription Factors during In Vitro Differentiation of Mouse Embryonic Stem Cells into Hepatocytes. Drug Metabolism and Pharmacokinetics 23(3), 188-195(2008)
2. ベストダウンロード論文賞
(DMPK Award for the Most Frequently Downloaded Article in 2007)
1) Review Article
1st Place
著者，所属：Shigeru KAWAKAMI and Mitsuru HASHIDA
(Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University)
論文題目：Targeted Delivery Systems of Small Interfering RNA by Systemic Administration. Drug Metabolism and Pharmacokinetics 22(3), 142-151(2007)
2nd Place
著者，所属：Masahiro HAYASHI and Mikio TOMITA
(Department of Drug Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)
論文題目：Mechanistic Analysis for Drug Permeation Through Intestinal Membrane. Drug Metabolism and Pharmacokinetics 22(2), 67-77(2007)
3rd Place
著者，所属：Kiyohiko SUGANO, Arimichi OKAZAKI, Shohei SUGIMOTO, Sumitra TAVORNVIPAS, Atsushi OMURA and Takashi MANO
(Global Research & Development, Nagoya Laboratories, Pharmaceutical R&D, Pfizer Inc.)
論文題目： Solubility and Dissolution Profile Assessment in Drug Discovery. Drug Metabolism and Pharmacokinetics 22(4), 225-254(2007)
2) Original Article
1st Place
著者，所属： Masanori KUBO1), Toshiko KOUE1), Hiromi MAUNE1), Tsuyoshi FUKUDA2) and Junichi AZUMA2)
(1)Department of Clinical Research and Development, Otsuka Pharmaceutical Co., Ltd.,2)Clinical Pharmacology and Pharmacogenomics, Graduate School of Pharmaceutical Sciences, Osaka University)
論文題目： Pharmacokinetics of Aripiprazole, a New Antipsychotic, following Oral Dosing in Healthy Adult Japanese Volunteers: Influence of CYP2D6 Polymorphism. Drug Metabolism and Pharmacokinetics 22(5), 358-366(2007)
2nd Place
著者，所属： Hiromi FUKUSHIMA-UESAKA1), Yoshiro SAITO1)2), Keiko MAEKAWA1)2), Naoyuki KAMATANI3), Hiroshi KAJIO4), Nobuaki KUZUYA4), Mitsuhiko NODA4), Kazuki YASUDA5) and Jun-ichi SAWADA1)2)
(1)Project Team for Pharmacogenetics, National Institute of Health Sciences,2)Division of Biochemistry and Immunochemistry, National Institute of Health Sciences,3) Division of Genomic Medicine, Department of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University,4)Division of Endocrine and Metabolic Diseases, the Hospital, International Medical Center of Japan,5)Department of Metabolic Disorder, Research Institute, International Medical Center of Japan)
論文題目： Genetic Variations and Haplotype Structures of Transcriptional Factor Nrf2 and Its Cytosolic Reservoir Protein Keap1 in Japanese. Drug Metabolism and Pharmacokinetics 22(3), 212-219(2007)
3rd Place
著者，所属： Yoshiteru KAMIYAMA1)2), Tsutomu MATSUBARA1)3), Kouichi YOSHINARI1), Kiyoshi NAGATA1)4), Hidetaka KAMIMURA2) and Yasushi YAMAZOE1)3)
(1)Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University,2) Drug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma Inc.,3) Tohoku University 21st Century, COE Program “Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation”,4)Department of Environmental Health Science, Tohoku Pharmaceutical University)
論文題目：Role of Human Hepatocyte Nuclear Factor 4α in the Expression of Drug-Metabolizing Enzymes and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA. Drug Metabolism and Pharmacokinetics 22(4), 287-298(2007)
3. ベストサイテーション論文賞
(DMPK Award for the Most Frequently Cited Article in 2005)
1) Review Article
1st Place
著者，所属：Toshiyuki SAKAEDA
(Department of Hospital Pharmacy, School of Medicine, Kobe University and Division of Clinical Pharmacokinetics, Department of General Therapeutics, Faculty of Medicine & Division of Biomedical Sciences, Kobe University Graduate School of Medicine)
論文題目：MDR1 Genotype-related Pharmacokinetics: Fact or Fiction? Drug Metabolism and Pharmacokinetics 20(6), 391-414(2005)
2nd Place
著者，所属：Takahisa FURUTA1), Naohito SHIRAI2), Mitsushige SUGIMOTO1), Akiko NAKAMURA1), Akira HISHIDA1) and Takashi ISHIZAKI3)
(1)First Department of Medicine, Hamamatsu University School of Medicine,2)Department of Laboratory Medicine, Hamamatsu University School of Medicine,3)Department of Clinical Pharmacology and Pharmacy, School of Pharmaceutical Sciences, Teikyo-Heisei University)
論文題目：Influence of CYP2C19 Pharmacogenetic Polymorphism on Proton Pump Inhibitor-based Therapies. Drug Metabolism and Pharmacokinetics 20(3),153-167(2005)
3rd Place
著者，所属：Miki NAKAJIMA and Tsuyoshi YOKOI
(Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University)
論文題目： Interindividual Variability in Nicotine Metabolism: C-Oxidation and Glucuronidation. Drug Metabolism and Pharmacokinetics 20(4), 227-235(2005)
2) Original Article
1st Place(1)
著者，所属：Naoko KIMURA, Satohiro MASUDA, Yuko TANIHARA, Harumasa UEO, Masahiro OKUDA, Toshiya KATSURA and Ken-ichi INUI
(Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University)
論文題目：Metformin is a Superior Substrate for Renal Organic Cation Transporter OCT2 rather than Hepatic OCT1. Drug Metabolism and Pharmacokinetics 20(5), 379-386(2005)
1st Place(2)
著者，所属：Masuhiro NISHIMURA and Shinsaku NAITO
(Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc)
論文題目： Tissue-specific mRNA Expression Profiles of Human ATP-binding Cassette and Solute Carrier Transporter Superfamilies. Drug Metabolism and Pharmacokinetics 20(6), 452-477(2005)
3rd Place
著者，所属：Akiko MATSUI-SAKATA1), Hisakazu OHTANI2) and Yasufumi SAWADA2)
(1)Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 2) Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo)
論文題目： Receptor Occupancy-based Analysis of the Contributions of Various Receptors to Antipsychotics-induced Weight Gain and Diabetes Mellitus. Drug Metabolism and Pharmacokinetics 20(5), 368-378(2005)