日本薬物動態学会
会長 杉山雄一
編集委員長 千葉 寛
2007年度DMPK三賞が決定しましたのでお知らせします。各賞の第一位の論文（総説、原著論文）の全著者について、第22回年会時に盾あるいは賞状の授賞式を行います。
1. ベストダウンロード論文賞(DMPK Award for the Most frequently Downloaded article in 2005)
1) Review Article
1st Place
著者，所属：Takahisa FURUTA1), Naohito SHIRAI2), Mitsushige SUGIMOTO1), Akiko NAKAMURA1), Akira HISHIDA1) and Takashi ISHIZAKI3)
(1) First Department of Medicine, 2) Department of Laboratory Medicine, Hamamatsu University School of Medicine,3) Department of Clinical Pharmacology and Pharmacy, School of Pharmaceutical Sciences, Teikyo-Heisei University)
論文題目：Influence of CYP2C19 Pharmacogenetic Polymorphism on Proton Pump Inhibitor-based Therapies. Drug Metabolism and Pharmacokinetics 20(3), 153-167(2005)
2nd Place
著者，所属：Toshiyuki SAKAEDA
(Department of Hospital Pharmacy, School of Medicine, Kobe University and Division of Clinical Pharmacokinetics, Department of General Therapeutics, Faculty of Medicine & Division of Biomedical Sciences, Kobe University Graduate School of Medicine)
論文題目：MDR1 Genotype-related Pharmacokinetics: Fact or Fiction?Drug Metabolism and Pharmacokinetics 20(6), 391-414(2005)
3rd Place
著者，所属：Yoshimichi SAI
(Department of Pharmaceutics, Kyoritsu University of Pharmacy)
論文題目：Biochemical and Molecular Pharmacological Aspects of Transporters as Determinants of Drug Disposition. Drug Metabolism and Pharmacokinetics 20(2), 91-99(2005)
2) Original Article
1st Place
著者，所属：Masuhiro NISHIMURA and Shinsaku NAITO
(Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.)
論文題目：Tissue-specific mRNA Expression Profiles of Human ATP-binding Cassette and Solute Carrier Transporter Superfamilies. Drug Metabolism and Pharmacokinetics 20(6), 452-477(2005)
2nd Place
著者，所属：Masuhiro NISHIMURA1), Tsuyoshi YOKOI2), Chise TATENO3), Miho KATAOKA3), Eiji TAKAHASHI4), Toru HORIE4,5), Katsutoshi YOSHIZATO3,6) and Shinsaku NAITO1)
(1) Division of Pharmacology, Drug Safety and Metabolism; Otsuka Pharmaceutical Factory, Inc.,2) Division of Drug Metabolism and Toxicology; Faculty of Pharmaceutical Sciences; Kanazawa University,3) Hiroshima Prefectural Institute of Industrial Science and Technology, CLUSTER,4) PhoenixBio Co., Ltd.,5) D three Research Laboratories,6) Graduate School of Science, Hiroshima University)
論文題目：Induction of Human CYP1A2 and CYP3A4 in Primary Culture of Hepatocytes from Chimeric Mice with Humanized Liver. Drug Metabolism and Pharmacokinetics 20(2), 121-126(2005)
3rd Place
著者，所属：Akiko MATSUI-SAKATA1), Hisakazu OHTANI2) and Yasufumi SAWADA2)
(1) Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University,2) Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo)
論文題目：Receptor Occupancy-based Analysis of the Contributions of Various Receptors to Antipsychotics-induced Weight Gain and Diabetes Mellitus. Drug Metabolism and Pharmacokinetics 20(5), 368-378(2005)
2. ベストサイテーション論文賞(DMPK Award for the Most Frequently Cited Article in 2003)
1) Review Article
1st Place
著者，所属：Toshiya KATSURA and Ken-ichi INUI
(Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University)
論文題目：Intestinal Absorption of Drugs Mediated by Drug Transporters: Mechanisms and Regulation.Drug Metabolism and Pharmacokinetics 18(1), 1-15(2003)
2nd Place
著者，所属：Yoshihiko FUNAE, Wataru KISHIMOTO, Toshio CHO, Toshiro NIWA and Toyoko HIROI
(Department of Chemical Biology, Osaka City University, Medical School)
論文題目：CYP2D in the Brain. Drug Metabolism and Pharmacokinetics 18(6), 337-349(2003)
3rd Place
著者，所属：Shinsaku NAKAGAWA and Tadanori MAYUMI
(Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University)
論文題目：Development of Novel Technology of DDS for Gene Therapy. Drug Metabolism and Pharmacokinetics 18(4), 223-229(2003)
3rd Place
著者，所属：Tetsuya SUGA
(School of Pharmacy, Tokyo University of Pharmacy and Life Science)
論文題目：Drug Metabolism in Peroxisomes: Involvement of Peroxisomal β-Oxidation System in the Oxidative Chain-shortening of Xenobiotic Acyl Compounds. Drug Metabolism and Pharmacokinetics 18(3), 155-162(2003)
2) Original Article
1st Place
著者，所属：Takako SHIMIZU1), Hirohide OCHIAI2), Fredrik ASELL2), Hiroshi SHIMIZU2), Ryuta SAITOH2), Yoshimasa HAMA2), Jun KATADA1), Munehiro HASHIMOTO1)2), Hitoshi MATSUI1), Katsuhiko TAKI3), Tsuguchika KAMINUMA4), Michiko YAMAMOTO4), Yoshitaka AIDA1)2), Akira OHASHI1)2) and Naoki OZAWA1)2)
(1) Pharmacia,2) Advanced Research Institute for Science and Engineering, Waseda University,3) Nihon Visual Science,4) National Institute of Health Sciences)
論文題目：Bioinformatics Research on Inter-racial Difference in Drug Metabolism I. Analysis on Frequencies of Mutant Alleles and Poor Metabolizers on CYP2D6 and CYP2C19. Drug Metabolism and Pharmacokinetics 18(1), 48-70(2003)
2nd Place
著者，所属：Masaya ITODA1), Yoshiro SAITO1)2), Kuniaki SHIRAO3), Hironobu MINAMI4), Atsushi OHTSU5), Teruhiko YOSHIDA7), Nagahiro SAIJO8), Hiroshi SUZUKI9), Yuichi SUGIYAMA9), Shogo OZAWA1)6) and Jun-ichi SAWADA1)2)
(1) Project team for Pharmacogenetics, National Institute of Health Sciences,2) Division of Biochemistry and Immunochemistry, National Institute of Health Sciences,3) Gastrointestinal Oncology Division, National Cancer Center Hospital, National Cancer Center Research Institute,4) Division of Oncology/Hematology, National Cancer Center Hospital East,5) Division of GI Oncology/Digestive Endoscopy, National Cancer Center Hospital East,6) Division of Pharmacology, National Institute of Health Sciences,7) Genetics Division, National Cancer Center Research Institute,8) Medical Oncology Division, National Cancer Center Hospital, National Cancer Center Research Institute,9) Graduate School of Pharmaceutical Sciences, The University of Tokyo)
論文題目：Eight Novel Single Nucleotide Polymorphisms in ABCG2/BCRP in Japanese Cancer Patients Administered Irinotacan. Drug Metabolism and Pharmacokinetics 18(3), 212-217(2003)
3rd Place
著者,所属：Yoshihisa SHITARA1), Albert P. LI2), Yukio KATO3), Chuang LU2), Kiyomi ITO1), Tomoo ITOH1) and Yuichi SUGIYAMA3)
(1) School of Pharmaceutical Sciences, Kitasato University,2) In Vitro Technologies, Inc,3) Graduate School of Pharmaceutical Sciences, University of Tokyo)
論文題目：Function of Uptake Transporters for Taurocholate and Estradiol 17β-D-Glucuronide in Cryopreserved Human Hepatocytes. Drug Metabolism and Pharmacokinetics 18(1), 33-41(2003)
3. 編集委員が選ぶ最優秀論文賞 (DMPK Editors’ Award for the Most Excellent Article in 2006)
1st Place
著者，所属: Tomoko SUGIURA, Yukio KATO, Yoshiyuki KUBO and Akira TSUJI(Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University)
論文題目：Mutation in an Adaptor Protein PDZK1) Affects Transport Activity of Organic Cation Transporter OCTNs and Oligopeptide Transporter PEPT2). Drug Metabolism and Pharmacokinetics 21(5), 375-383(2006)
(最終選考に残った他の論文)
著者，所属：Wachiraporn NORACHARTTIYAPOT1), Yoko NAGAI1), Tsutomu MATSUBARA1)2), Masaaki MIYATA1), Miki SHIMADA1), Kiyoshi NAGATA1) and Yasushi YAMAZOE1)2)
(1) Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University,2) Comprehensive Research and Education Center for Planning of Drug Development and Clinical Education, Tohoku University 21st Century Center of Excellence Program)
論文題目：Construction of Several Human-derived Stable Cell Lines Displaying Distinct Profiles of CYP3A4 Induction.Drug Metabolism and Pharmacokinetics 21(2), 99-108(2006)
著者，所属：Svetlana MARKOVA1), Tsutomu NAKAMURA2), Toshiyuki SAKAEDA1),2), Hiroo MAKIMOTO2), Hitoshi UCHIYAMA1), Noboru OKAMURA3) and Katsuhiko OKUMURA1),2),3)
(1) Division of Clinical Pharmacokinetics, Kobe University Graduate School of Medicine,2) Department of Hospital Pharmacy, School of Medicine, Kobe University,3) Department of Clinical Evaluation of Pharmacotherapy, Kobe University Graduate School of Medicine)
論文題目：Genotype-dependent Down-regulation of Gene Expression and Function of MDR1 in Human Peripheral Blood Mononuclear Cells under Acute Inflammation. Drug Metabolism and Pharmacokinetics21(3), 194-200(2006)
著者，所属：Masuhiro NISHIMURA and Shinsaku NAITO
(Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.）
論文題目：Tissue-Specific mRNA Expression Profiles of Human Phase I Metabolizing Enzymes Except for Cytochrome P450 and Phase II Metabolizing Enzymes. Drug Metabolism and Pharmacokinetics 21(5), 357-374(2006)