Newsletter Volume 39, Number 6, 2024

Newsletter Volume 39, Number 6, 2024

Introduction

 The year 2024 is just around the corner. This year has seen many events, such as the 50-50, Japan’s first generation of Japanese, and the new paper currency, which have become the topic of conversation. In the field of science, the Nobel Prizes in Chemistry and Physics were both awarded in the field of AI. On the other hand, there were also natural disasters and other difficult events. I would like to express my deepest sympathies to those who have been affected by these disasters. It has been a very eventful year, and I wonder what the next year will bring. I hope it will be a good year for all of you.

 Thank you for reading our newsletter this year. We will continue to provide you with a variety of information and look forward to your continued support and cooperation. (T.I.)

NEW POWER for pharmacokinetic research

Contributing to Drug Discovery through the Development of Prediction Methods for Human Pharmacokinetics

Mitsubishi Tanabe Pharma Corporation Pharmacokinetics Research Laboratories

Mitsusa Yoshida

 My name is Mitsusa Yoshida and I am with the Pharmacokinetics Research Laboratories, Mitsubishi Tanabe Pharma Corporation. I would like to thank the editorial board members of the newsletter for this valuable opportunity to write this article. I joined Mitsubishi Tanabe Pharma Corporation in 2009 after completing a master’s degree at Kyoto Pharmaceutical University Graduate School, and have been engaged in corporate pharmacokinetic research for 16 years. I have contributed to the promotion of in-house projects through the development of human pharmacokinetic prediction methods in the company’s research. I would like to introduce my past work in the company. … ( To be continued at NL website / Members only )

Academic Society Signposts

Participating in the 26th North American ISSX and 39th JSSX Meeting

Laboratory of Molecular Pharmacotherapeutics, Kanazawa University

Yukiko Yamaguchi

 Thank you very much for selecting my presentation for the FY2024 Support Program for Young Researchers to Present Their Research Overseas. I would like to express my sincere gratitude to Dr. Masao Kato, President of the Japanese Pharmacokinetics Society, and the other members of the selection committee. I participated in the 26th NAISSX/39th JSSX held on September 15-18, 2024, and presented my paper “Optimization of linker sequence of aminopeptidase A-Fc fusion proteins in pharmacokinetics and The recombinant protein of aminopeptidase A (APA) (rhAPA) is a high-molecular weight and is expected to be an antihypertensive modality with low placental delivery. We optimized the sequence of rhAPA and evaluated its pharmacokinetics and pharmacological activity. … ( To be continued at NL website )

Support for Young Researchers to Present Their Research Abroad in FY2024

Department of Pharmacokinetics and Pharmacodynamics, Graduate School of Pharmaceutical Sciences, Nagoya City University

Kaito Matsui

 The 26th NAISSX/39th JSSX Meeting was held in Honolulu, Hawaii, USA, September 15-18, 2024. I have been selected for the “Support Program for Young Researchers to Present Their Research Abroad” and participated in this meeting. I would like to express my sincere gratitude to Dr. Masao Kato, President of the Japanese Society of Pharmacokinetics, Dr. Miki Nakajima, Chair of the Committee for the Promotion of Internationalization, and other members of the selection committee for their support. This was my first overseas presentation and my first visit to a foreign country. It was a very valuable opportunity for me to gain various new experiences. I would be happy if I could share some of my experiences with you. … ( To be continued at NL website )

Participation in the 26th North American ISSX and 39th JSSX Meeting

Department of Pharmacy, Kitasato University Graduate School of Pharmaceutical Sciences

Shota Fukada

 Thank you very much for selecting me as a recipient of the FY2024 Support Program for Young Researchers’ Overseas Presentations. I would like to express my sincere gratitude to Dr. Masao Kato, President of the Japanese Pharmacokinetics Society, and the other members of the selection committee. I participated in the 26th NAISSX/39th JSSX held on September 15-18, 2024, and presented my paper “ESTABLISHMENT OF A NOVEL IN VITRO ASSAY SYSTEM WITH CRYPT-DERIVED DIFFERENTIATED INTESTINAL CELLS TO EVALUATE DRUG-INDUCED GASTROINTESTINAL TOXICITY CAUSED BY THE DISRUPTION OF MUCUS LAYER”. I hope that I can share with readers what I experienced and felt through my participation in this conference. … ( To be continued at NL website )

Participating in the 26th North American ISSX and 39th JSSX Meeting

Laboratory of Pharmacognosy, Department of Pharmacy and Natural Medicine, Academic Research Division, University of Toyama

Kiyotaka Ookohara

 The 39th Annual Meeting of the Japanese Society of Pharmacokinetics (JSSX) and the 26th North American ISSX Meeting were held in Honolulu, Hawaii, USA, from September 15 to 18, 2024. I was selected by the Japanese Pharmacokinetic Society as a recipient of the 2024 Overseas Presentation Support Program for Young Researchers, and was able to participate in the meeting with its support. I would like to express my sincere gratitude to Dr. Masao Kato, President of the Japanese Pharmacokinetic Society, Dr. Miki Nakajima, Chair of the Committee for the Promotion of Internationalization, and other members of the selection committee.

 I made a poster presentation entitled “Effect of lipopolysaccharide on P-glycoprotein at the inner blood-retinal barrier in vivo ” at this meeting. … ( To be continued on the NL website )

Participation in the 26th North American ISSX and 39th JSSX Meeting

Laboratory of Drug Metabolism and Safety, Department of Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kanazawa University

Mari Nagaoka

 Thank you very much for selecting my presentation for the FY2024 Support Program for Young Researchers to Present Their Research Abroad. We would like to express our sincere gratitude to Dr. Masao Kato, President of the Japanese Pharmacokinetics Society, Dr. Miki Nakajima, Chair of the Committee for the Promotion of Internationalization, and other members of the selection committee.

 I attended the 26th North American ISSX and 39th JSSX Meeting held in Honolulu, Hawaii, USA, from September 15 to 18, 2024, and presented a poster entitled “Mechanism by which AADAC regulates hepatic lipid levels in vivo A poster presentation entitled “Mechanism by which AADAC regulates hepatic lipid level in vivo ” was given. … ( To be continued at NL website )

Participation in the 26th North American ISSX and 39th JSSX Meeting

Department of Medical Pharmacology, Chugai Pharmaceutical Co.

Department of Medical Pharmacology, Chugai Pharmaceutical Co.

 I participated in the 26th North American ISSX and 39th JSSX Meeting held in Honolulu, Hawaii, USA, on September 15-18, 2024, with the support of the Japanese Society of Pharmacokinetics (JSPS) Young Investigator Overseas Presentation Support Program. I would like to express my sincere gratitude to Dr. Masao Kato, President of the Japanese Society of Pharmacokinetics, and the other members of the selection committee for selecting me for this program.

 I would like to present “QUANTITATIVE PREDICTION OF P-GP/CYP3A SUBSTRATE DRUG ABSORPTION IN HUMANS USING A MONOLAYER MODEL DERIVED FROM INTESTINAL ORGANOIDS” at this meeting. I made a poster presentation titled “ORGANOIDS”. … ( To be continued at NL website )