日本薬物動態学会
会長 山添 康
編集委員長 千葉 寛
2008年度DMPK三賞が決定しましたのでお知らせします。各賞の第一位の論文（総説、原著論文）の全著者について、第23回年会時に盾あるいは賞状の授賞式を行います。また、第三位までの論文とその著者については、ニュースレターおよび学会のホームページで公表し、顕彰します。
1. ベストダウンロード論文賞(DMPK Award for the Most frequently Downloaded article in 2006)
1) Review Article
1st Place
著者，所属：Yasuhiro MASUBUCHI
(Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chiba Institute of Science)
論文題目：Metabolic and Non-Metabolic Factors Determining Troglitazone Hepatotoxicity: A Review.Drug Metabolism and Pharmacokinetics 21(5), 347-356(2006)
2nd Place
著者，所属：Tsutomu SHIMADA(Department of Chemical Biology, Osaka City University Medical School)
論文題目：Xenobiotic-Metabolizing Enzymes Involved in Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons.Drug Metabolism and Pharmacokinetics 21(4), 257-276(2006)
3rd Place
著者，所属：Teruko IMAI(Graduate School of Pharmaceutical Sciences, Kumamoto University)
論文題目： Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design. Drug Metabolism and Pharmacokinetics 21(3), 173-185(2006)
2) Original Article
1st Place
著者，所属： Masuhiro NISHIMURA1), Akiko KOEDA2), Emako SUZUKI2), Yuichi KAWANO1), Mitsuo NAKAYAMA1), Tetsuo SATOH2)3), Shizuo NARIMATSU4) and Shinsaku NAITO1)
(1)Department of Drug Metabolism, Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.,2)Ina Research Inc.,3)Non-Profit Organization Human & Animal Bridging Research Organization,4)Laboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University)
論文題目： Regulation of mRNA Expression of MDR1, MRP1, MRP2 and MRP3 by Prototypical Microsomal Enzyme Inducers in Primary Cultures of Human and Rat Hepatocytes. Drug Metabolism and Pharmacokinetics 21(4), 297-307(2006)
2nd Place
著者，所属： Masuhiro NISHIMURA and Shinsaku NAITO
(Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.)
論文題目： Tissue-Specific mRNA Expression Profiles of Human Phase I Metabolizing Enzymes Except for Cytochrome P450 and Phase II Metabolizing Enzymes. Drug Metabolism and Pharmacokinetics 21(5),357-374(2006)
3rd Place
著者，所属： Yoshiyuki SHIRASAKA1), Masae KAWASAKI1), Toshiyasu SAKANE1), Hideaki OMATSU2), Yuka MORIYA2), Tsutomu NAKAMURA2), Toshiyuki SAKAEDA2), Katsuhiko OKUMURA2), Peter LANGGUTH3) and Shinji YAMASHITA1)
(1)Faculty of Pharmaceutical Sciences, Setsunan University,2)Department of Hospital Pharmacy, School of Medicine, Kobe University,3)School of Pharmacy, Johannes Gutenberg-University)
論文題目：Induction of Human P-Glycoprotein in Caco-2 cells: Development of a Highly Sensitive Assay System for P-Glycoprotein-Mediated Drug Transport. Drug Metabolism and Pharmacokinetics 21(5), 414-423(2006)
2. ベストサイテーション論文賞(DMPK Award for the Most Frequently Cited Article in 2004)
1) Review Article
1st Place
著者，所属：Junya NAGAI and Mikihisa TAKANO(Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University)
論文題目： Molecular Aspects of Renal Handling of Aminoglycosides and Strategies for Preventing the Nephrotoxicity. Drug Metabolism and Pharmacokinetics 19(3), 159-170(2004)
2nd Place
著者，所属： Hiroyuki TSUDA1)2), Yutaka OHSHIMA1), Hiroshi NOMOTO2), Ken-ichi FUJITA2), Eiji MATSUDA2), Masaaki IIGO2), Nobuo TAKASUKA2) and Malcolm A. MOORE1)2)
(1)Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences,2)Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute)
論文題目：Cancer Prevention by Natural Compounds. Drug Metabolism and Pharmacokinetics 19(4), 245-263(2004)
3rd Place
著者，所属：Tsuyoshi MIKKAICHI3), Takehiro SUZUKI1)4), Masayuki TANEMOTO1), Sadayoshi ITO1) and Takaaki ABE1)2)
(1)Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine,2)PRESTO, Japan Science and Technology Agency (JST), 3)Department of Clinical Pharmacy, Tohoku University Graduate School of Pharmaceutical Sciences,4)21century COE program)
論文題目： The Organic Anion Transporter (OATP) Family. Drug Metabolism and Pharmacokinetics19(3), 171-179(2004)
2) Original Article
1st Place
著者，所属：Masuhiro NISHIMURA1), Shinsaku NAITO1) and Tsuyoshi YOKOI2)
(1)Department of Drug Metabolism, Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.,2)Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University)
論文題目： Tissue-specific mRNA Expression Profiles of Human Nuclear Receptor Subfamilies. Drug Metabolism and Pharmacokinetics 19(2), 135-149(2004)
2nd Place
著者，所属：Rieko TACHIBANA-IIMORI1), Yasuharu TABARA2), Hiroyuki KUSUHARA3), Katsuhiko KOHARA1), Ryuichi KAWAMOTO4), Jun NAKURA1), Katsushi TOKUNAGA5), Ikuko KONDO2), Yuichi SUGIYAMA3) and Tetsuro MIKI1)
(1)Department of Geriatric Medicine, Ehime University School of Medicine,2)Department of Medical Genetics, Ehime University School of Medicine,3)Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo,4)Department of Internal Medicine, Nomura Municipal Hospital,5)Department of Human Genetics, Graduate School of Medicine, The University of Tokyo)
論文題目： Effect of Genetic Polymorphism of OATP-C (SLCO1B1) on Lipid-Lowering Response to HMG-CoA Reductase Inhibitors. Drug Metabolism and Pharmacokinetics 19(5), 375-380(2004)
3rd Place
著者，所属：Satoshi YAMAORI1), Hiroshi YAMAZAKI1), Shunsuke IWANO1), Kazuma KIYOTANI1), Keiko MATSUMURA1), Goro HONDA2), Kazuko NAKAGAWA3), Takashi ISHIZAKI3) and Tetsuya KAMATAKI1)
(1)Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University,2)Saiseikai Kumamoto Hospital,3)Department of Pharmacology and Therapeutics, Graduate School of Clinical Pharmacy, Kumamoto University)
論文題目： CYP3A5 Contributes Significantly to CYP3A-mediated Drug Oxidations in Liver Microsomes from Japanese Subjects. Drug Metabolism and Pharmacokinetics 19(2), 120-129(2004)
3rd Place
著者,所属：Kaori MORIMOTO1), Tomoharu OISHI1), Shiro UEDA2), Madoka UEDA1), Masakiyo HOSOKAWA1) and Kan CHIBA1)
(1)Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University,2)Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University)
論文題目：A Novel Variant Allele of OATP-C (SLCO1B1) Found in a Japanese Patient with Pravastatin-induced Myopathy. Drug Metabolism and Pharmacokinetics 19(6), 453-455(2004)
3. 編集委員が選ぶ最優秀論文賞 (DMPK Editors’ Award for the Most Excellent Article in 2007)
1st Place
著者，所属: Ai TAMURA1)4), Yuko ONISHI1), Ran AN1), Shoko KOSHIBA1), Kanako WAKABAYASHI1)4), Kazuyuki HOSHIJIMA1), Waldemar PRIEBE2), Takashi YOSHIDA3), Satoshi KOMETANI3), Takayoshi MATSUBARA3), Kenta MIKURIYA3) and Toshihisa ISHIKAWA1)
(1)Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology,2)Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center,3)Drug Discovery Solution Department, Life Science Business Headquarters, Yokogawa Electric Corporation,4)Japanese Society for the Promotion of Science (JSPS) Research Fellow)
論文題目：In Vitro Evaluation of Photosensitivity Risk Related to Genetic Polymorphisms of Human ABC Transporter ABCG2 and Inhibition by Drugs. Drug Metabolism and Pharmacokinetics 22(6), 428-440(2007)
2nd Place
著者，所属： Yuji ISHII1), Megumi IWANAGA1), Yoshio NISHIMURA1), Shuso TAKEDA1), Shin-ichi IKUSHIRO2), Kiyoshi NAGATA3)4), Yasushi YAMAZOE4), Peter I. MACKENZIE5) and Hideyuki YAMADA1)
(1)Graduate School of Pharmaceutical Sciences, Kyushu University,2)Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University,3)Department of Environmental and Health Science, Tohoku Pharmaceutical University,4)Graduate School of Pharmaceutical Sciences, Tohoku University,5)Department of Clinical Pharmacology, Flinders Medical Centre and Flinders University)
論文題目： Protein-Protein Interactions between Rat Hepatic Cytochromes P450 (P450s) and UDP-Glucuronosyltransferases (UGTs): Evidence for the Functionally Active UGT in P450-UGT Complex.Drug Metabolism and Pharmacokinetics 22(5), 367-376(2007)
2nd Place
著者，所属： Yoshiteru KAMIYAMA1)2), Tsutomu MATSUBARA1)3), Kouichi YOSHINARI1), Kiyoshi NAGATA1)4), Hidetaka KAMIMURA2) and Yasushi YAMAZOE1)3)
(1)Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University,2)Drug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma Inc.,3)Tohoku University 21st Century, COE Program “Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation”,4)Department of Environmental Health Science, Tohoku Pharmaceutical University)
論文題目： Role of Human Hepatocyte Nuclear Factor 4α in the Expression of Drug-Metabolizing Enzymes and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA. Drug Metabolism and Pharmacokinetics 22(4), 287-298(2007)