Newsletter Volume 39, Number 1, 2024
Introduction
First of all, we would like to express our deepest sympathies to all those affected by the Noto Peninsula earthquake that occurred on January 1. We sincerely hope for your safety and a speedy recovery.
Since last year, in addition to the political fund party issue in Japan, there have been a series of events in the world of entertainment that have exposed the old pus. Looking at the world, the ongoing conflict between Ukraine and Russia, the advance of Israeli forces into the Gaza Strip in Palestine, and the attack by U.S. and British forces on a militia stronghold in Yemen, all remind us of the turbulent and confusing times we are living through. On the other hand, there is also bright news that reminds us of a new era in a positive sense. In the field of science, last year the NIH updated the reference sequence of the human genome, the PanGenome, for the first time in about 20 years. Compared to the previous reference sequence, the new sequence has much greater racial diversity, and is expected to be very useful for the development of personalized medicine in the future. In addition, the use and development of generative AI, such as ChatGPT, progressed dramatically last year. Technology (semantic decoder) has been developed that can recover words, phrases, and sentences from brain activity while listening to audio, and can also recover sentences that explain the content of a scene from brain activity while watching a silent video.
The year 2024 is the year of the Chinese zodiac sign “Ki-no-Etsu” (甲辰). The “Kou” in the Chinese zodiac sign of “Koujin” is the first of the ten signs of the Chinese zodiac and has the meaning of the beginning or growth of things. For us pharmacokinetic researchers, I hope that this year will also be a year in which we will be able to produce a succession of groundbreaking research results and ideas that will be of real value to patients suffering from diseases, in conjunction with the development of cutting-edge science and technology!
At the General Assembly of Delegates held last November, the 18th term officers including President Masao Kato and Vice President Hiroyuki Kusuhara were inaugurated, and the Newsletter Committee has started its activities under a new structure, including the replacement of some members. We will continue to make efforts to produce attractive contents of the Newsletter as a place for information exchange among members and information dissemination from members so that we can contribute to the further development of pharmacokinetics research, even if only slightly. We look forward to your continued support. （Thank you very much for your continued support.)
Comments from the Award Winners
Receiving the Best Poster Award
Laboratory of Hygienic Pharmacy, Faculty of Pharmacy, Wakayama Medical University
Naoki Takaoka
I am very honored to receive the Best Poster Award for my presentation entitled “Metabolism of aldehyde odorants by nasal aldehyde-metabolizing enzymes and their inhibition by drugs” at the 38th Annual Meeting of the Japanese Pharmacokinetics Society. I am very honored to receive the prestigious Best Poster Award. … ( To be continued on the NL website )
Receiving the Best Poster Award
Laboratory of Drug Metabolism and Safety, Department of Drug Discovery Science, Kanazawa University Graduate School of Pharmaceutical Sciences
Yoshiyuki Sakai
I am very honored to receive the Best Poster Award for the presentation entitled “Role of hepatic arylacetamide deacetylase in cholesterol/bile acid homeostasis” at the 38th Annual Meeting of the Japanese Pharmacokinetic Society and the 23rd International Joint Meeting of the Cytochrome P450 International Conference. I am very honored to receive the Best Poster Award. … ( To be continued on the NL website )
Receiving the Best Poster Award
Laboratory of Human Organ/Tissue Models, Department of Laboratory Animal Research, Central Institute for Experimental Animals
Shotaro Uehara
I am very honored to receive the Best Poster Award for my presentation entitled “Metabolism and renal toxicity of SGX523 in chimeric mice with humanized liver” at the 38th Annual Meeting of the Japanese Pharmacokinetics Society. I would like to express my sincere gratitude to the selection committee members and all the people involved in the Japanese Society of Pharmacokinetics and Pharmacodynamics. … ( To be continued on the NL website )
Receiving the Best Poster Award
Department of Pharmacy, The University of Tokyo Hospital
Yoshihide Yamanashi
I am very honored to receive the Best Poster Award at the 38th Annual Meeting of the Japanese Pharmacokinetic Society for the presentation entitled “Hepatic NPC1L1 exacerbates NAFLD by suppressing biliary excretion of oxysterols”. I would like to express my sincere gratitude to the judges and all the people involved in the Japanese Society of Pharmacokinetics and Pharmacodynamics. … ( To be continued on the NL website )
Receiving the Best Poster Award
Mitsubishi Tanabe Pharma Corporation
Laboratory of Pharmacokinetics, Drug Discovery Headquarters, Mitsubishi Tanabe Pharma Corporation
Thank you very much for selecting my presentation entitled “Mechanism of inhibition and transport of human SGLT2-MAP17 glucose transporter” for the Best Poster Award at the 38th Annual Meeting of the Japanese Pharmacokinetics Society. Thank you very much. I would like to express my deepest gratitude to all those who were involved in the conference organization and the award selection process. … ( To be continued on the NL website )
Receiving the Best Poster Award
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima
Hiroaki Yada
I am very honored to receive the Best Poster Award at the 38th Annual Meeting of the Japanese Society of Pharmacokinetics for my presentation entitled “Glucose transporter-mediated transport of newly synthesized creatine analog in human blood-brain barrier endothelial cells” at the 38th Annual Meeting of the Japanese Society of Pharmacokinetics. Thank you very much for the Best Poster Award for the presentation entitled “Glucose transporter-mediated transport of newly synthesized creatine analog in human blood-brain barrier endothelial cells”. … ( To be continued on the NL website )
Receiving the Best Poster Award
Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kanazawa University
Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kanazawa University
I was awarded the Best Poster Award at the 38th Annual Meeting of the Japanese Society of Pharmacokinetics and the 23rd International Joint Meeting of the Cytochrome P450 Society for the Study of Drug Induced Kidney Injury using 3D-cultured kidney epithelial cells. The Best Poster Award was given to “Utility of high content analysis of drug-induced kidney injury using 3D-cultured kidney epithelial cells”. We would like to express our sincere gratitude to Dr. Koichi Yoshinari, Dr. Shingo Nagano, the Congress Chair, and all the people involved in the Japanese Society of Pharmacokinetics and Pharmacodynamics. … ( To be continued on the NL website )
Receiving the Best Poster Award
Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Yoshiki Hashimoto
I am very honored to receive the Best Poster Award at the 38th Annual Meeting of the Japanese Pharmacokinetic Society and the 23rd International Joint Meeting of the Cytochrome P450 International Conference. I would like to express my sincere gratitude to Dr. Koichi Yoshinari and Dr. Shingo Nagano, the President of the conference, the selection committee members, and all the people involved in the Japanese Pharmacokinetics Society. … ( To be continued on the NL website )
Receiving the Best Poster Award
Department of Personalized Pharmacotherapy, Tokyo University of Pharmacy and Life Sciences
Seiya Ohki
I am very honored to receive the prestigious Best Poster Award at the 38th Annual Meeting of the Japanese Pharmacokinetics Society and the 23rd International Joint Meeting of the Cytochrome P450 International Conference. I would like to take this opportunity to express my sincere appreciation to the selection committee members and everyone involved. … ( To be continued on the NL website )
Best Poster Award -comment from the winner
Siyu Liu
Center of Excellence for Drug Metabolism, Pharmacokinetics and Modeling
Preclinical and Translational Sciences, Research, Takeda Pharmaceutical Company Limited
I’m deeply pleased and honored to receive the best poster award from expert professionals of the JSSX for our presentation entitled ‘Establishment of a workflow for spatial pharmacokinetics analysis using three-dimensional (3D) microscopic imaging data ‘. It’s our privilege to be recognized by the JSSX committee.
Receiving the Best Poster Award
Takeda Pharmaceutical Company Limited Pharmacokinetic Research Laboratories
Miyu Nakayama
We are pleased to announce that we received the Best Poster Award at the 38th Annual Meeting of the Japanese Society of Pharmacokinetics and Pharmacodynamics for our poster entitled “Microenvironmental pharmacokinetic/pharmacodynamic analysis of antisense oligonucleotides: in situ hybridization with super-resolution microscopy and direct The Best Poster Award was given for the presentation entitled “Microenvironmental pharmacokinetic/pharmacodynamic analysis of antisense oligonucleotides: in situ hybridization with super-resolution microscopy and direct nuclear isolation. I am honored to receive such a prestigious award. … ( To be continued at the NL website )
NEW POWER for kinetic research
Fascinated by Novel Transporters
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
Takato Tomabechi
My name is Takato Tomabechi, Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University. I would like to thank the editorial board members and everyone involved for the opportunity to contribute to the newsletter of the Japanese Pharmacokinetics Society. I entered the Faculty of Pharmaceutical Sciences, Tokyo University of Pharmacy and Life Sciences in 2013 and started my research career in the Department of Pharmacokinetics and Pharmacodynamics led by Professor Katsuo Inoue in my fourth year. In April of the same year, I joined the Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, led by Dr. Kazuya Maeda, and have been entrusted with research and, to a lesser extent, lecturing. I am about to enter my ninth year of teaching (though it has been less than a year since I started teaching).
Antibody Drug Conjugate (ADC) Pharmacokinetic Studies
Part 3: Bioanalysis of ADCs – How to quantify complex components? –
Pharmacokinetics Research Laboratories, Daiichi Sankyo Company, Limited
Hiroshi Habara
Good afternoon! Since the last issue, I have been writing about “Introduction to Antibody Drug Conjugate (ADC) Pharmacokinetic Studies”. In this third article, I would like to talk about bioanalysis (analysis of drug concentration in biological samples) of ADCs.
First, I would like to talk about the subject of analysis. In order to understand the pharmacokinetics of ADCs with complex molecular structures, it is necessary to analyze each component derived from the molecular structure. The Draft Guidance (1) for clinical pharmacology studies of ADCs issued by the FDA in February 2022 recommends that ADCs with at least one payload, total antibody as the sum of all off-payloaded naked antibodies and ADCs, quantitation of the free payload and its active metabolites, and anti-drug antibody (ADA) evaluation be performed. … ( read more on the NL website / members only )