Newsletter Volume 38, Number 6, 2023
Introduction
In recent years, the use of artificial intelligence (AI) has expanded and many aspects of our lives have come to rely on its power. In the medical field, AI is used to support diagnosis and predict diseases, and in the field of science and technology, AI is used as a powerful tool for processing large amounts of data and making new discoveries. One such tool is ChatGPT, a natural language processing AI developed by OpenAI, which learns from large amounts of text data and generates natural dialogues.
When using ChatGPT, it is important to set up “prompts,” which are questions or commands to be given to the AI. Although ChatGPT has only just begun to take off, its potential is immeasurable. If ChatGPT can be utilized in the field of pharmacokinetics to set optimal prompts, it could lead to the discovery of new treatments and the development of revolutionary new drugs. In fact, the manuscript of this “Introduction” was written with the help of ChatGPT, and we feel that we are truly paving a new path together with AI.
We hope you will enjoy this issue of our newsletter as well. (Y.K.)
Topics
Pharmacokinetics Newsletter: Regulatory Science Information
The Newsletter Committee reports on regulatory science information related to the field of pharmacokinetics, including the latest trends in guidelines and regulatory harmonization activities at ICH. … ( To be continued on the NL website / Members Only )
Comments from the Award Winners
On Receiving the Society’s Award
(Department of Clinical Pharmacology, Nagoya City University Graduate School of Pharmaceutical Sciences)
Tamihide Matsunaga
I am honored to receive the Japanese Society for Pharmacokinetics and Pharmacodynamics (JSPS) Award for “Development of human iPS cell-derived cells useful for pharmacokinetic studies. I would like to express my sincere gratitude to Dr. Tomiyoshi Yamashita, President of the Japanese Society of Pharmacokinetics, the members of the Board of Directors, the members of the Selection Committee for the Society Award, and other related scientists. I would also like to express my sincere gratitude to Dr. Katsunori Nakamura, Professor and Director of the Department of Pharmacy, University of the Ryukyus Hospital, for his recommendation for this award. … ( To be continued on the NL website )
Receiving the Encouragement Award
Laboratory of Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
Hiroto Hatakeyama
I am very honored to receive the 2023 Incentive Award from the Japanese Society of Pharmacokinetics and Pharmacodynamics for the title of “Study on Pharmacokinetic Factors Influencing the Pharmacodynamics and Adverse Effects of Immune Checkpoint Inhibitors”. I would like to express my sincere gratitude to Dr. Akihiro Hisaka of Chiba University for his recommendation, and to the President, Vice-Presidents, Directors, and Selection Committee members of the Japanese Pharmacokinetic Society. I started this research in January 2016 after returning to Japan from studying in the United States and joining the Hisaka Laboratory in the Graduate School of Pharmaceutical Sciences, Chiba University. … ( To be continued on the NL website )
Receiving the Encouragement Award
Laboratory of Molecular Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Kanazawa University
Yusuke Masuo
I am honored to receive the prestigious 2023 Incentive Award from the Japanese Society of Pharmacokinetics and Pharmacodynamics (JSPS) for “Identification of Substrates of Membrane Transporters in Vivo by Structure-Selective Metabolomics”. I would like to express my sincere gratitude to Professor Masao Kato of Kanazawa University, the selection committee members, and the members of the executive committee for recommending me for the award. In this paper, I would like to introduce my work on metabolomics optimized for the functional analysis of membrane transporters, which was the subject of the award. … ( To be continued on the NL website )
Drug Discovery Contribution and Encouragement Award
Otsuka Pharmaceutical Co.
Katsunori Sasahara
I am honored to receive the 2023 Drug Discovery Contribution Award for “Basic Research on Drug Screening Using Robotics, IT, Machine Learning and Computational Chemistry”. I am deeply honored to receive this very prestigious award. I would like to express my sincere gratitude to the officers of the Japanese Pharmacokinetics Society, the members of the selection committee, and Dr. Eiji Kashiyama of Otsuka Pharmaceutical Co. I have been engaged in in silico research throughout my research career, and I would like to express my sincere gratitude to Dr. Eiji Kashiyama of Otsuka Pharmaceutical Co. I would like to introduce my research activities in the following. … ( To be continued at the NL homepage )
Conference Signposts
Participation in the 25th North American ISSX
Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Yoshiki Hashimoto
The 25th North American ISSX Meeting was held in Boston, Massachusetts, USA, on September 10-13, 2023. I participated in this meeting as a recipient of the “Support Program for Young Researchers to Present Their Research Abroad” for the second semester of fiscal year 2023. I would like to express my sincere gratitude to Dr. Tomiyoshi Yamashita, President of the Japanese Pharmacokinetics Society, Dr. Miki Nakajima, Chair of the Internationalization Committee, and other members of the selection committee. This was my first time to participate in an international conference, and at the same time it was my first trip abroad. I would be happy if I could share my experience with you, the readers. … ( To be continued on the NL website )
Support for Young Researchers’ Overseas Presentations in FY2023 (Second Semester)
Department of Pharmacokinetics and Pharmacodynamics, Graduate School of Pharmaceutical Sciences, Nagoya City University
Isamu MATAKE
I participated in the 25th NA ISSX meeting held in Boston, Massachusetts, USA, September 10-13, 2023, with the support of the Japanese Society of Pharmacokinetics for Young Scientists to present my paper “FUNCTIONAL CHARACTERIZATION OF ENT2/SLC29A2 AS A The poster presentation was entitled “FUNCTIONAL CHARACTERIZATION OF ENT2/SLC29A2 AS A URIC ACID TRANSPORTER”. The involvement of transporters in the membrane permeation process of uric acid is well known due to its high water solubility. However, information on the transporters involved in the blood transport of uric acid in the liver and small intestine, which are uric acid-producing organs, is still scarce. … ( visit the NL website for more information )