Newsletter Volume 38, Number 5, 2023
Introduction
While the political and economic situation in Ukraine and the soaring prices of commodities continue to be difficult, there is a lot of excitement in the world of sports these days. In the basketball World Cup, under the leadership of coach Tom Horvath, the players have made remarkable progress, winning three games with tenacity, and successfully qualified for the Paris Olympics on their own. Following basketball, the team played a strong game in the rugby World Cup against a powerful country and came very close to breaking through the qualifying league following the last World Cup. In Japanese professional baseball, the Hanshin Tigers, led by Okada, won the league championship for the first time in 18 years by actively promoting young players who have matured. The Orix Buffaloes, also in Kansai, won the league championship for the third consecutive year, and depending on the result of the Climax Series, the Kansai Derby in the Japan Series will be realized. I believe that these remarkable achievements in the sports world will cheer up the world and give us all courage and hope.
Similarly, in the field of science, such as pharmacokinetics, when researchers’ originality and ingenuity produce research results that are useful for culture and industry, I believe that this will energize the world. In this newsletter, we would like to provide you with the latest information on pharmacokinetics and pharmacodynamics research, as well as behind-the-scenes information on the research, and the thoughts and feelings of the professors who devote themselves to their research. The articles in this month’s issue are also interesting, so please take a look at them. (S.O.)
NEW POWER for pharmacokinetic research
Toxicology Research Based on Pharmacokinetics
Akinori Takemura, Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
My name is Akinori Takemura, Graduate School of Pharmaceutical Sciences, Chiba University. I would like to express my gratitude to the editorial board members and others involved in this project for the opportunity to contribute to the newsletter of the Japanese Society of Pharmacokinetics and Toxicology, “NEW POWER for Pharmacokinetics Research. I entered the Faculty of Pharmaceutical Sciences at Chiba University in 2010 and was assigned to the Biopharmaceutics Laboratory, which was led by Professor Toshiharu Horie in January 2013, when I was a third-year undergraduate student. Prof. Horie retired in March of the same year, and I was engaged in hepatotoxicity research under the guidance of Prof. Akinari Ito, who arrived at the same time I was assigned to the lab, until the doctoral course. I was engaged in hepatotoxicity research under the guidance of Professor Akinari Ito, who arrived at the same time I was assigned to the laboratory.
Antibody Drug Conjugate (ADC) Pharmacokinetic Studies
Part 2: Pharmacokinetic Evaluation of ADCs: Trastuzumab Deluxecan as an Example
Yoko Nagai, Laboratory of Pharmacokinetics, Daiichi Sankyo Company, Limited
Hello! Since the last issue, we have been providing you with “Introduction to Pharmacokinetic Studies of Antibody Drug Conjugates (ADCs)”. In this second issue, I would like to report on the pharmacokinetic studies of ADCs. In the previous issue, we discussed that in oncology, ADCs deliver their payloads to target tumor tissues, relatively reducing the exposure of the payload in normal tissues. In other words, ADCs are a modality that broadens the therapeutic window by altering the distribution of the payload in the body compared to when the payload is administered alone. Furthermore, pharmacokinetic studies play a significant role in the research and development of ADCs because the pharmacokinetics of an ADC changes depending on the structure and combination of its components (antibody, linker, and payload). … ( To be continued at NL Website / Members Only )
Adme Circle
Welcome to Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University – Let’s hear the real voices! ～Kazuya Maeda
Kazuya Maeda
AdmeCircle is a project to introduce pharmacokinetic research organizations in Japan. In this issue, Professor Kazuya Maeda of the Department of Pharmacology, Kitasato University School of Pharmaceutical Sciences will introduce his laboratory and research themes in a video presentation. This is the first attempt of its kind and is a “tour de force” completed by Prof. Maeda with his great efforts. Please take a look. Please check it out… (For the video, please visit the NL homepage )