日本薬物動態学会 | The Japanese Society for the Study of Xenobiotics

メインメニュー

会務関連のお知らせ

2025.05.12: 薬物動態学の基礎講座の参加申込を開始しました（6/26まで）。
2025.05.12: 2025年度　学会賞および功労賞　候補者の推薦募集を延長いたしました（6/2まで）
2025.04.10: 2025年度若手研究者海外発表支援事業（14th International ISSX Meeting）の募集を開始しました（5/19まで）。
2025.03.30: 第19期理事選挙に係る理事候補者の応募期間を延長いたしました（4/14まで）。
2025.02.10: 2025年度学会賞、奨励賞、創薬貢献・北川賞、創薬貢献・奨励賞、功労賞　候補者の推薦募集を開始しました（5/7まで）。

学術集会関連のお知らせ

2025.03.11: 第40回年会（京都）の一般演題募集を開始しました。
2025.02.25: 学生・若手企業研究者シンポジウム（PRIS2025）の発表者を募集しています（4/30まで）。
2025.02.25: 国際薬物動態学会第14回国際会議（9/21～24、米国シカゴ）では一般演題を募集しています（5/4まで）。
2024.12.11: 第40回年会（京都）のホームページが開設されました！
2024.10.23: 若手研究者海外発表支援事業採用者の26th NAISSX/39th JSSX参加レポートが掲載されました。

その他のお知らせ

2025.05.12: 関連学会情報を更新しました: 「杉山雄一教授・城西国際大学（JIU）退官記念公開シンポジウム」を掲載しました。
2025.04.25: 関連学会情報を更新しました: 「2025年度ファーマコメトリクス・人材育成コース」を掲載しました。
2025.04.25: 関連学会情報を更新しました: 「日本薬剤学会第40年会」を掲載しました。
2025.04.25: ニュースレター・メールマガジン, Vol.40(2)を発行しました
2025.03.25: 関連学会情報を更新しました: 「第46回生体膜と薬物の相互作用シンポジウム」を掲載しました。

Drug Metabolism and Pharmacokinetics

Latest Issue

Drug Metabolism and Pharmacokinetics (DMPK) は日本薬物動態学会 (JSSX) および国際薬物動態学会 (ISSX) の公式オンラインジャーナルです。

Go DMPK (Vo.17, 2002〜current issue)

過去のDMPK (Vo.17, 2002〜Vol. 29, 2014)

テーマ号（Special Issues and Article Collections）

2023 Impact Factor = 2.7　CiteScore = 4.8

	DMPK Editors’ Award for the Most Excellent Article in 2022 【1st place】 Yasuto Kido^, Isamu Nanchi, Yasuyuki Fusamae, Takanobu Matsuzaki, Takanori Akazawa, Hiromi Sawada, Makoto Iwasaki, Kimiko Nishida, Eiichi Tsuchiya, Tomohiko Okuda Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse. Volume 42, 100426, February 2022. https://doi.org/10.1016/j.dmpk.2021.100426 【2nd place】 Takayoshi Nakaoka, Ken-ichi Kaneko, Satsuki Irie, Aya Mawatari, Ami Igesaka, Yuta Uetake, Hidenori Ochiai, Takashi Niwa, Emi Yamano, Yasuhiro Wada, Masaaki Tanaka, Kohei Kotani, Hideki Kawahata, Joji Kawabe, Yukio Miki, Hisashi Doi, Takamitsu Hosoya, Maeda Kazuya, Hiroyuki Kusuhara, Yuichi Sugiyama, Yasuyoshi Watanabe^ Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity. Volume 44, 100449, June 2022. https://doi.org/10.1016/j.dmpk.2022.100449 【3rd place】 Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Kenji Kawai, Masafumi Yamamoto, Hidetaka Kamimura, Yuichi Iida, Mitsuo Oshimura, Yasuhiro Kazuki, Hiroshi Yamazaki, Hayato Hikita, Tetsuo Takehara, Hiroshi Suemizu^* An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals. Volume 42, 100410, February 2022. https://doi.org/10.1016/j.dmpk.2021.100410
	DMPK Editors' Award for the Most Excellent Article in 2021 【1st Place】 Yukihiro Shibata, Yuta Tamemoto, Sheelendra Pratap Singh, Aoi Yoshitomo, Shizuka Hozuki, Hiromi Sato, Akihiro Hisaka^* Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6. Volume 39, 100396, August 2021. https://doi.org/10.1016/j.dmpk.2021.100396 【2nd Place】 Katsunori Sasahara, Masakazu Shibata, Hiroyuki Sasabe, Tomoki Suzuki, Kenji Takeuchi, Ken Umehara, Eiji Kashiyama Predicting drug metabolism and pharmacokinetics features of in-house compounds by a hybrid machinelearning model. Volume 39, 100395, August 2021. https://doi.org/10.1016/j.dmpk.2021.100395 【3rd Place】 Chikako Shibazaki, Tomoyuki Ohe, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino^ Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites. Volume 39, 100386, August 2021. https://doi.org/10.1016/j.dmpk.2021.100386
	DMPK Editors' Award for the Most Excellent Article in 2020 【1st Place】 6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients Yusuke Masuo, Ken-ichi Fujita, Kenji Mishiro, Natsumi Seba, Tatsuya Kogi, Hidenori Okumura, Natsumi Matsumoto, Munetaka Kunishima, Yukio Kato Volume 35, Issue 6, Pages 555-562 https://doi.org/10.1016/j.dmpk.2020.09.001 【2nd Place】 Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells Tomoki Kabeya, Shinji Mima, Yuki Imakura, Toshihide Miyashita, Izumi Ogura, Tadanori Yamada, Tomoya Yasujima, Hiroaki Yuasa, Takahiro Iwao, Tamihide Matsunaga Volume 35, Issue 4, Pages 374-382 https://doi.org/10.1016/j.dmpk.2020.04.334 【3rd Place】 Quantitative application of flow cytometry for the analysis of circulating human T cells: A preclinical pharmacokinetic study Syunsuke Yamamoto, Shin-Ichi Matsumoto, Hisao Shimizu, Hideki Hirabayashi Volume 35, Issue 2, Pages 207-213 https://doi.org/10.1016/j.dmpk.2019.11.003
	DMPK Editors' Award for the Most Excellent Article in 2019 【1st Place】 Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers Daiki Mori, Yushi Kashihara, Takashi Yoshikado, Miyuki Kimura, Takeshi Hirota, Shunji Matsuki, Kazuya Maeda, Shin Irie, Ichiro Ieiri, Yuichi Sugiyama, Hiroyuki Kusuhara Volume 34, Issue 1, Pages 78-86 https://doi.org/10.1016/j.dmpk.2018.09.003 【2nd Place】 Quantitative investigation of hepatobiliary transport of [¹¹C]telmisartan in humans by PET imaging Kazuya Maeda, Akihito Ohnishi, Masahiro Sasaki, Yasuhiko Ikari, Kazuki Aita, Yasuyoshi Watanabe, Hiroyuki Kusuhara, Yuichi Sugiyama, Michio Senda Volume 34, Issue 5, Pages 293-299 https://doi.org/10.1016/j.dmpk.2019.02.004 【3rd Place】 Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney Tomoko Kito, Sumito Ito, Tadahaya Mizuno, Kazuya Maeda, Hiroyuki Kusuhara Volume 34, Issue 1, Pages 87-94 https://doi.org/10.1016/j.dmpk.2018.08.005 【3rd Place】 Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients Nora Lee, Kazuya Maeda, Shinya Fukizawa, Ichiro Ieiri, Atsuko Tomaru, Hironobu Akao, Kenji Takeda, Mizuho Iwadare, Osamu Niwa, Tougen Masauji, Naoe Yamane, Kouji Kajinami, Hiroyuki Kusuhara, Yuichi Sugiyama Volume 34, Issue 6, Pages 387-395 https://doi.org/10.1016/j.dmpk.2019.08.004
	DMPK Editors' Award for the Most Excellent Article in 2018 【1st Place】 Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model Tomohisa Nakada, Toshiyuki Kudo, Toshiyuki Kume, Hiroyuki Kusuhara, Kiyomi Ito Volume 33, Issue 1, Pages 103-110, 2018 https://doi.org/10.1016/j.dmpk.2017.11.314 【2nd Place】 miR-141-3p commonly regulates human UGT1A isoforms via different mechanisms Naoyuki Tatsumi, Shinsaku Tokumitsu, Masataka Nakano, Tatsuki Fukami, Miki Nakaj ima Volume 33, Issue 4, Pages 203-210, 2018 https://doi.org/10.1016/j.dmpk.2018.05.002 【3rd Place】 Physiological based pharmacokinetic modeling to estimate in vivo Ki of ketoconazole on renal P-gp using human drug-drug interaction study result of fesoterodine and ketoconazole Masayo Oishi, Yuma Takano, Yutaka Torita, Bimal Malhotra, Koji Chiba Volume 33, Issue 1, Pages 90-95, 2018 https://doi.org/10.1016/j.dmpk.2017.11.005
	DMPK Editors' Award for the Most Excellent Article in 2017 【1st Place】 Quantitative prediction of therapeutic antibody pharmacokinetics after intravenous and subcutaneous injection in human Kenta Haraya, Tatsuhiko Tachibana, Junichi Nezu Volume 32, Issue 4, 2017, Pages 208-217 https://doi.org/10.1016/j.dmpk.2017.05.002 【2nd Place】 Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates Toru Takenaka, Kanako Kazuki, Naomoto Harada, Jiro Kuze, Masato Chiba, Takahiro Iwao, Tamihide Matsunaga, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki Volume 32, Issue 1, 2017, Pages 61-68 https://doi.org/10.1016/j.dmpk.2016.08.004 【3rd Place】 Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data Kayoko Kanamitsu, Yoshitane Nozaki, Yoko Nagaya, Yuichi Sugiyama, Hiroyuki Kusuhara Volume 32, Issue 2, 2017, Pages 135-144 https://doi.org/10.1016/j.dmpk.2016.11.007
	DMPK Editors' Award for the Most Excellent Article in 2016 【1st Place】 Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments Kanamitsu K., Arakawa R., Sugiyama Y., Suhara T., Kusuhara H. Vol. 31 (2016) No. 6 p. 395-404 http://www.sciencedirect.com/science/article/pii/S1347436716300441 【2nd Place】 Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(−/−) rats Nagaya Y., Nozaki Y., Takenaka O., Watari R., Kusano K., Yoshimura T., Kusuhara H. Vol. 31 (2016) No. 1 p. 57-66 http://www.sciencedirect.com/science/article/pii/S1347436715000622 【3rd Place】 Inhibition of mitogen-activated protein kinase kinase, DNA methyltransferase, and transforming growth factor-β promotes differentiation of human induced pluripotent stem cells into enterocytes Kodama N., Iwao T., Kabeya T., Horikawa T., Niwa T., Kondo Y., Nakamura K., Matsunaga T. Vol. 31 (2016) No. 3 p. 193-200 http://www.sciencedirect.com/science/article/pii/S134743671600015X 【3rd Place】 Development of a permeability-limited model of the human brain and cerebrospinal fluid(CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data Gaohua L., Neuhoff S., Johnson T.N., Rostami-Hodjegan A., Jamei M. Vol. 31 (2016) No. 3 p. 224-233 http://www.sciencedirect.com/science/article/pii/S1347436716300088 【3rd Place】 Appropriate risk criteria for OATP inhibition at the drug discovery stage based on the clinical relevancy between OATP inhibitors and drug-induced adverse effect Nakakariya M., Goto A., Amano N. Vol. 31 (2016) No. 5 p. 333-339 http://www.sciencedirect.com/science/article/pii/S1347436716300234 ... Go DMPK (Vo.17, 2002〜current issue)

学術集会

ポスター画像：第40回日本薬物動態学会（JSSX）年会（2025年）

第40回日本薬物動態学会（JSSX）年会

日時	2025年10月20日（月）～10月23日（木）
会場	京都市勧業館「みやこめっせ」
年会長	山下富義（京都大学大学院薬学研究科）

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